Antigen Atlas & Typing

Red Blood Cell (RBC) and Platelet (PLT) antigen genotype to phenotype correlations.
Developed to type RBC and PLT antigens from next generation sequencing (NGS).

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Name Gene
ABO ABO
MNS GYPA
MNS GYPB
MNS GYPE
P1PK A4GALT
Rh RHD
Rh RHCE
Lutheran LU
Lutheran KLF1
Lutheran GATA1
Kell KEL
Lewis FUT3
Duffy DARC
Kidd SLC14A1
Diego SLC4A1
Yt ACHE
Xg XG
Xg CD99
Scianna ERMAP
Dombrock ART4
Colton AQP1
Landsteiner-Wiener ICAM4
Chido/Rodgers C4B
Chido/Rodgers C4A
H FUT1
H FUT2
H SLC35C1
Kx XK
Gerbich GYPC
Cromer CD55
Knops CR1
Indian CD44
Ok BSG
Raph CD151
John Milton Hagen SEMA7A
I GCNT2
Globoside B3GALNT1
Gill AQP3
Rh-associated glycoprotein RHAG
FORS GBGT1
Jr ABCG2
Lan ABCB6
Vel SMIM1
CD59 CD59
Augustine SLC29A1
Total 45

For more information on RBC blood groups terminology and official lists of alleles please use the following external link:
ISBT - Blood Groups
Database v1.14 [2017-07-02 23:00]
Typing Algorithm v3.3 [2017-05-24 23:00]
Typing Pipeline v3.3 [2017-05-24 23:00]
Name Gene
Integrin beta-3 ITGB3
Platelet glycoprotein Ib alpha chain GP1BA
Integrin alpha-IIb ITGA2B
Integrin alpha-2 ITGA2
Platelet glycoprotein Ib beta chain GP1BB
CD109 antigen CD109
Platelet glycoprotein 4 CD36
Total 7

*These numbers are just to help more easily identify each genes and are not the actual HPA System Numbers.

Similar to RBC Blood Group antigen the Human Platelet Antigen (HPAs) are each defined by antigen specific alloantibody sera.
However, unlike the RBC Blood Groups Systems, the HPA Systems were not named on a per gene or related gene basis with one or more antigens in each system.
Rather, one HPA gene can contain multiple HPA systems so in reality each biallelic antithetical antigen pair is really its own system.
For example, the HPA-1 system contains the antithetical antigens HPA-1a and HPA-1b, but this same gene also contains the HPA-4 system (HPA-4a and HPA-4b).
A 'w' after an HPA name indicates that no alloantibody has ever been found directed against this antigen's antithetical pair.

All of our HPA amino acid changes are in reference to the full length protein. There might be some difference in positions to other sources which list these amino acid changes in reference to positions in cleaved mature proteins.

For more information about HPA terminology and official allele lists please visit the following external link: IPD-HPA Database